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Anand AC, Nightingale P, Neuberger JM

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We advise against the use of these medications for individuals with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2

All of these factors can contribute to poor production of glutathione (or of the enzymes that help glutathione to do its work), and many also deplete the GSH that the cells produce (by converting it into GSSG)

A double-blind, randomized, placebo-controlled crossover study of memantine monotherapy (60 patients, 43 completed) found no significant improvement in Tinnitus Handicap Inventory scores compared with placebo, leading the authors to conclude that the study does not provide evidence to recommend memantine for tinnitus treatment (Figueiredo et al., 2008)

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